Magnesium Metabolism of Human and Rabbit Erythrocytes

Magnesium metabolism of human and rabbit erythrocytes.

By STANLEY GINSBURG, JAMES G. Sxirni, FREEMAN M. GINSBURG, JACQUELINE Z. REARDON AND JERIIY K. AIKAWA T HE CURRENT PAUCITY of information concerning magnesium metabolism in erythrocytes is due in part to the lack of a reliable method for determining magnesium in red cells, and in part to the fact that a radioactive isotope of magnesium suitable for tracer studies has only recently become availa...

Adenosine Metabolism in Human Erythrocytes

Phosphoinositide metabolism and the morphology of human erythrocytes

ATP-depleted human erythrocytes lose their smooth discoid shape and adopt a spiny, crenated form. This shape change coincides with the conversion of phosphatidylinositol-4,5-bisphosphate to phosphatidylinositol and phosphatidic acid to diacylglycerol. Both crenation and lipid dephosphorylation are accelerated by iodoacetamide, and both are reversed by nutrient supplementation. The observed chan...

Nitrite uptake and metabolism and oxidant stress in human erythrocytes.

Nitric oxide, when released into the bloodstream, is quickly scavenged by Hb in erythrocytes or oxidized to nitrite. Nitrite can also enter erythrocytes and oxidize Hb. The goals of this work were to determine the mechanism of erythrocyte nitrite uptake and whether this uptake causes oxidant stress in these cells. Erythrocytes took up 0.8 mM nitrite with a half-time of 11 min. Nitrite uptake wa...

Magnesium Metabolism

Magnesium is the second most common intracellular divalent cation. Magnesium balance in the body is controlled by a dynamic interplay among intestinal absorption, exchange with bone, and renal excretion. Intestinal magnesium absorption proceeds in both a passive paracellular and an active transcellular manner. Regulation of serum magnesium concentrations is achieved mainly by control of renal m...